英文名字 Anti-D1 Dopamine Receptor
中文名称 D1 Dopamine 受体抗体(0.2 ml)
供应商 Alomone
产品货号 ALO-ADR-001-0.2
产品报价 ¥7600/0.2ml
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产品新闻
背景资料 The D1 Dopamine Receptor (D1 Receptor) is one of five receptors that mediate the effects of the catecholamine neurotransmitter dopamine. Dopamine regulates a variety of functions including locomotor activity, emotion, positive reinforcement, food intake, and hormone secretion. The dopaminergic system has been extensively studied in the last thirty years mainly because its dysregulation has been linked to several neurological and neuropsychiatric diseases including Parkinson’s disease and schizophrenia.
All five dopamine receptors belong to the 7-transmembrane domain, G-Protein Coupled Receptor (GPCR) superfamily.
Historically, the five receptors have been divided into two subfamilies based on pharmacological and structural considerations: the D1-like subfamily (that includes the D1 and D5 subtypes) and the D2-like subfamily (that includes the D2-, D3- and D4 subtypes).
The D1-like Receptors are coupled to Gs-type G proteins and enhance adenylate cyclase activity while the D2-like Receptors are coupled to Gi-type G proteins and inhibit adenylate cyclase activity.
The D1 Receptor is widely distributed throughout the brain with the highest expression in the cerebral cortex and striatum. In the periphery the D1 Receptor has been detected in the adrenal cortex, kidney and heart.
Functionally, the D1 Receptor has been implicated in the regulation of both locomotor and cognitive functions including the maintaining of spontaneous motor behaviors, the control of working memory and cognition as well as the regulation of craving and reward pathways.
In addition, D1 Receptor plays an important role in the pathogenesis of hypertension by regulating epithelial Na+ transport and by interacting with vasoactive hormones/humoral factors, such as aldosterone and angiotensin.
应用类型 经验证,该抗体可应用于IH、WB等实验。
免疫原 D1 Dopamine 受体抗体的免疫原肽段为SSHHEPRGSISKDC。此免疫原序列来源于372-385 位氨基酸残基,该序列来源于大鼠D1 Dopamine 受体 (Accession编号为P18901)。胞内, C端。
来源宿主
反应性 反应性:小鼠、 大鼠
保存建议 艾美捷为您提供的D1 Dopamine 受体抗体(0.2 ml)为室温运输,建议您收到产品后㧟20℃保存。
产品说明书
其他 Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技购乐彩票将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

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