英文名字 Anti-CXCR4 (extracellular)
中文名称 CXCR4 (胞外)抗体(0.2 ml)
供应商 Alomone
产品货号 ALO-ACR-014-0.2
产品报价 ¥7600/0.2ml
购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。
产品新闻
背景资料 CXCR4 was originally identified as an orphan receptor, and soon gained much attention when it was discovered as a coreceptor for HIV-14. Besides from being involved in HIV-1 infection/progression, CXCR4 is found to be upregulated in many different cancers/tumors and has evolved to become a target for the development of antagonists5. CXCL12 (SDF-1α) is the sole ligand for CXCR4. Following binding of its ligand, CXCR4 undergoes dimerization and activates Gi G-proteins6,7. However downstream activation through CXCR4 could also occur through other G-proteins and non-G-proteins5. The down regulation of the CXCR4 receptor is initiated by phosphorylation of its cytoplasmic tail, which is followed by the binding of arrestin. The receptor is then internalized through endocytosis and degraded in the lysosome. Downregulation of CXCR4 could also occur through the stimulation of other GPCRs8.
The distribution of CXCR4 is quite broad and involves the central nervous system (CNS)9, spleen, testes, hematopoietic and non-hematopoietic cells.
应用类型 经验证,该抗体可应用于IFC、IH、WB等实验应用,也可用于IC、IP、LCI等实验。
免疫原 CXCR4 (胞外)抗体的免疫原肽段为(C)EGISIYTSDNYTEE。此免疫原序列来源于2-15位氨基酸残基,该序列来源于人类CXCR4 (Accession编号为 P61073)。胞外,N端。
来源宿主
反应性 反应性:人、 小鼠、 大鼠
保存建议 艾美捷为您提供的CXCR4 (胞外)抗体(0.2 ml)为室温运输,建议您收到产品后㧟20℃保存。
产品说明书
其他 Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技购乐彩票将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

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