英文名字 Anti-TRPC7 (extracellular)
中文名称 TRPC7 (胞外)抗体(50 ul)
供应商 Alomone
产品货号 ALO-ACC-066-50
产品报价 ¥5872/50ul
购买方式 银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我们电话联系400-6800-868。
产品新闻
背景资料 The TRPC subfamily is further divided into the following: TRPC1/4/5, TRPC3/6/7 and TRPC21. Activation of phospholipase C (PLC) ultimately leads to the formation of diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) via hydrolysis of PIP2. The increase in concentration of these intracellular second messengers leads to the activation of non-selective Ca2+ channels and an IP3-induced release of Ca2+ from intracellular stores5. The intracellular Ca2+ store depletion in turn activates Ca2+ specific channels to allow replenish intracellular Ca2+ levels. TRPCs are thought to be activated upon intracellular store Ca2+ depletion, and may function in concert along with the recently identified Orai channel5. The TRPC3/6/7 class produces similar currents upon activation.
TRPC7 is activated by a broad range of hormones and neurotrophins, many of which activate PLC dependent pathways, via G-protein coupled receptors (GPCRs) or receptor tyrosine kinases (RTKs). Its expression is has been detected in dorsal root ganglia (DRGs), heart, uterine myometrium, keratinocytes and leukemic cells.In myocardial cells, TRPC7 has recently been shown to promote apoptosis, thereby becoming a contributing factor in the development of heart disease. Indeed, there is a strong correlation between the high expression level of TRPC7 and apoptosis in hearts from Dahl salt-sensitive rats which have suffered from heart failure.
应用类型 经验证,该抗体可应用于IC、LCI、WB等实验应用,也可用于IFC、IH、IP等实验。
免疫原 TRPC7 (胞外)抗体的免疫原肽段为(C)DQHVQDDTLHNVS。此免疫原序列来源于504-516位氨基酸残基,该序列来源于人类TRPC7 (Accession编号为Q9HCX4 ),第二胞外环。
来源宿主
反应性 反应性:人、 小鼠、 大鼠
保存建议 艾美捷为您提供的TRPC7 (胞外)抗体(50 ul)为室温运输,建议您收到产品后㧟20℃保存。
产品说明书
其他 Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证,以冻干粉形式提供,可确保产品生物活性和保质期。Alomone可提供多种包装规格,灵活方便。作为Alomone Labs在中国的区域总代理,艾美捷科技购乐彩票将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。

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